Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_13
Snippet: While our WT strain is "culture-adapted," we found that it was far from a fitness peak; both WT 183 and 3D G64S increased their fitness ten-fold in approximately 40 cellular infection cycles (20 184 passages, Fig. 3A, Fig. S2 ). The difference in the rate of fitness gain between WT and 3D G64S 185 lineages was small but statistically significant (0.025 per passage, WT > 3D G64S ; mixed linear 186 effects model, p=0.0129)......
Document: While our WT strain is "culture-adapted," we found that it was far from a fitness peak; both WT 183 and 3D G64S increased their fitness ten-fold in approximately 40 cellular infection cycles (20 184 passages, Fig. 3A, Fig. S2 ). The difference in the rate of fitness gain between WT and 3D G64S 185 lineages was small but statistically significant (0.025 per passage, WT > 3D G64S ; mixed linear 186 effects model, p=0.0129).
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