Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_17
Snippet: These data suggest that, despite its two-fold reduction in mutation rate, 3D G64S is not mutation 194 limited, and that any adaptive benefit of a higher mutation rate is countered by the fitness cost of 195 increased mutational load (see Fig. 1F and 1G and associated model above)......
Document: These data suggest that, despite its two-fold reduction in mutation rate, 3D G64S is not mutation 194 limited, and that any adaptive benefit of a higher mutation rate is countered by the fitness cost of 195 increased mutational load (see Fig. 1F and 1G and associated model above).
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