Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics Document date: 2018_1_16
ID: dzorkks5_18
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint Next, we examined if aminoglycoside-mediated induction of antiviral immunity was specific 170 to the vaginal tract or if similar protection could be observed in other mucosal surfaces 171 such as the respiratory tract. A single intranasal dose of neomycin sufficed to significantly 172 upregulate ISG expression in the .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint Next, we examined if aminoglycoside-mediated induction of antiviral immunity was specific 170 to the vaginal tract or if similar protection could be observed in other mucosal surfaces 171 such as the respiratory tract. A single intranasal dose of neomycin sufficed to significantly 172 upregulate ISG expression in the lung (Fig. 3a) . To determine if this ISG induction results 173 in host antiviral resistance, we tested neomycin-mediated protection in a functionally 174 relevant mouse model of influenza infection. Many inbred mouse strains, including 175 C57BL/6, lack Mx1 (Ref. 13 ). Mx1 encodes the myxovirus resistance protein 1, a dynamin-176 like GTPase that blocks primary transcription of influenza by binding to viral nucleoproteins 177 14-17 . Mx1 is an ISG that is induced by neomycin treatment (Fig. 3a) , and when expressed, 178 confers resistance to influenza A virus in mice 14 . In mice lacking Mx1 such as C57BL/6 179 strains, innate resistance to influenza is abrogated, and they rely on adaptive immunity. 180
Search related documents:
Co phrase search for related documents- ISG induction and mouse model: 1
- ISG induction and neomycin treatment: 1, 2, 3, 4
- ISG induction and respiratory tract: 1, 2
- lung ISG expression and neomycin treatment: 1
- lung ISG expression and virus influenza: 1
- mouse model and mucosal surface: 1
- mouse model and respiratory tract: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- mouse model and similar protection: 1, 2
- mouse model and virus influenza: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- mouse strain and respiratory tract: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- mouse strain and similar protection: 1
- mouse strain and virus influenza: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- mucosal surface and respiratory tract: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- mucosal surface and virus influenza: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- myxovirus resistance protein and respiratory tract: 1, 2, 3, 4, 5
- myxovirus resistance protein and virus influenza: 1, 2, 3
- neomycin treatment and virus influenza: 1
- primary transcription and respiratory tract: 1
- primary transcription and virus influenza: 1
Co phrase search for related documents, hyperlinks ordered by date