Liposome composition in drug delivery design, synthesis, characterization, and clinical application.

Large, Danielle E; Abdelmessih, Rudolf G; Fink, Elizabeth; Auguste, Debra T

Liposomal drug delivery represents a highly adaptable therapeutic platform for treating a wide range of diseases. Natural and synthetic lipids, as well as surfactants, are commonly utilized in the synthesis of liposomal drug delivery vehicles. The molecular diversity in the liposome composition enables drug delivery with unique physiological functions, such as pH response, prolonged blood circulation, and reduced systemic toxicity. Herein, we discuss the impact of composition on liposome synthesis, function, and clinical utility.