Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways Document date: 2019_5_24
ID: cbit5xci_63
Snippet: Modification of chitosan with IAA also reduced its in vivo systemic toxicity. This result is fascinating because the in vivo systemic toxicity response to unmodified chitosan is not identical to the response to unmodified PEI. The in vivo systemic toxicity response of bPEI and chitosan shared elevated neutrophil levels in circulation, IL-6 levels in the serum, and CXCL1 levels in the spleen (Fig. 6B) . However, we found that liver toxicity and ch.....
Document: Modification of chitosan with IAA also reduced its in vivo systemic toxicity. This result is fascinating because the in vivo systemic toxicity response to unmodified chitosan is not identical to the response to unmodified PEI. The in vivo systemic toxicity response of bPEI and chitosan shared elevated neutrophil levels in circulation, IL-6 levels in the serum, and CXCL1 levels in the spleen (Fig. 6B) . However, we found that liver toxicity and changes in blood properties do not appear to play a major role in driving in vivo systemic toxicity to chitosan. Chitosan nanoparticles also increased serum levels of TNF-a and IL-1b, which is in agreement with studies demonstrating that chitosan activates the inflammasome pathway. [28, 35] [36] IAA All rights reserved. No reuse allowed without permission.
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