Author: Jacob E. Choby; Hanna B. Buechi; Allison J. Farrand; Eric P. Skaar; Matthew F. Barber
Title: Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus Document date: 2018_6_7
ID: ieh5cvw1_1
Snippet: Animals possess a variety of molecular factors that effectively sequester essential metals from 35 invasive microbes, contributing to an innate immune function termed nutritional immunity (1, 2). Iron, as 36 a critical cofactor for many host and bacterial enzymes, has provided the paradigm for our current 37 understanding of nutritional immunity. Since the discovery of iron limitation by egg white ovotransferrin 38 in the 1940s (3), mechanisms un.....
Document: Animals possess a variety of molecular factors that effectively sequester essential metals from 35 invasive microbes, contributing to an innate immune function termed nutritional immunity (1, 2). Iron, as 36 a critical cofactor for many host and bacterial enzymes, has provided the paradigm for our current 37 understanding of nutritional immunity. Since the discovery of iron limitation by egg white ovotransferrin 38 in the 1940s (3), mechanisms underlying nutritional immunity and bacterial iron scavenging have been 39 the subject of intense study (4). Many vertebrate-associated bacteria encode high affinity uptake systems 40 targeting heme, an abundant iron-containing porphyrin cofactor (5). 41
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