Author: Chunxi Zeng; Xucheng Hou; Jingyue Yan; Chengxiang Zhang; Wenqing Li; Weiyu Zhao; Shi Du; Yizhou Dong
Title: Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo Document date: 2020_4_5
ID: aju2nr9x_23
Snippet: This study describes a rational engineering approach to enhance protein production using mRNA. Through bioinformatics analysis and modification of endogenous 5' UTR and 3' UTR, followed by de novo design and further optimization, the most effective NASAR UTR was identified, enabling strong expression of multiple potential SARS-CoV-2 antigens both in vitro and in vivo......
Document: This study describes a rational engineering approach to enhance protein production using mRNA. Through bioinformatics analysis and modification of endogenous 5' UTR and 3' UTR, followed by de novo design and further optimization, the most effective NASAR UTR was identified, enabling strong expression of multiple potential SARS-CoV-2 antigens both in vitro and in vivo.
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