Author: Bauer, Jan; Wekerle, Hartmut; Lassmann, Hans
Title: Apoptosis in brain-specific autoimmune disease Cord-id: hc3jqpql Document date: 2002_2_11
ID: hc3jqpql
Snippet: Recent neuropathological studies of experimental autoimmune encephalomyelitis have focused attention on the high number of cells in the lesions that show typical morphological features of apoptosis. Surprisingly, it has turned out that the vast majority of apoptotic cells are T lymphocytes and that they actually represent the antigen-specific T-cell population responsible for the induction of the disease. Taken together, these data suggest that clearance of autoimmune inflammation in the nervous
Document: Recent neuropathological studies of experimental autoimmune encephalomyelitis have focused attention on the high number of cells in the lesions that show typical morphological features of apoptosis. Surprisingly, it has turned out that the vast majority of apoptotic cells are T lymphocytes and that they actually represent the antigen-specific T-cell population responsible for the induction of the disease. Taken together, these data suggest that clearance of autoimmune inflammation in the nervous system is accomplished by the destruction of the antigen-specific T-cell population within the lesions. This may explain the low level of central nervous system specific T-cell memory formation, as well as previously unexplained phenomena of ‘epitope spreading’, in autoimmune inflammation of the nervous system
Search related documents:
Co phrase search for related documents- absence presence and adhesion molecule: 1, 2, 3, 4
- active inflammation and local tissue: 1
Co phrase search for related documents, hyperlinks ordered by date