Selected article for: "clinical improvement and comprehensive treatment"
Author: Alfraji, Nasam; Mazahir, Usman; Chaudhri, Moiuz; Miskoff, Jeffrey
Title: Anti-synthetase syndrome: a rare and challenging diagnosis for bilateral ground-glass opacities—a case report with literature review
  • Cord-id: unq82nzu
  • Document date: 2021_1_6
    • ID: unq82nzu
    Snippet: BACKGROUND: Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud’s phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies. CASE PRESENTATION: We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on c
    Document: BACKGROUND: Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud’s phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies. CASE PRESENTATION: We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on chest imaging during the COVID-19 pandemic. High clinical suspicion for ASS with early appropriate therapy with corticosteroids and immunosuppressive agents led to marked clinical improvement. CONCLUSION: High index of suspicion for ASS is mandated in patients with unexplained ILD. A comprehensive autoimmune work-up is important as an early treatment with corticosteroids with or without immunomodulators improves patient outcomes and survival in an otherwise poor prognostic disease.

    Search related documents:
    Co phrase search for related documents
    • abdominal pain and long term outcome: 1, 2, 3
    • abdominal pain and low number: 1
    • abdominal pain and lung biopsy: 1
    • abdominal pain and lung biopsy bronchoscopy: 1
    • abdominal pain and lung disease: 1, 2, 3, 4, 5, 6, 7
    • abdominal pain and lung parenchymal: 1
    • abdominal pain and lung pattern: 1, 2, 3
    • abdominal pain and lymph node: 1, 2, 3, 4, 5, 6, 7, 8
    • acid fast stain and lung biopsy: 1
    • acid fast stain and lung disease: 1, 2
    • additional workup and lung disease: 1
    • admission prior and liver panel: 1
    • admission prior and low number: 1, 2
    • admission prior and lung biopsy: 1, 2, 3
    • admission prior and lung disease: 1, 2, 3, 4, 5, 6
    • admission prior and lung parenchymal: 1
    • admission prior and lv function: 1, 2, 3
    • admission prior and lymph node: 1, 2
    • liver panel and lung biopsy: 1