Author: Wu Liu; Mehmet U. Caglar; Zhangming Mao; Andrew Woodman; Jamie J. Arnold; Claus O. Wilke; Craig E. Cameron
Title: More than efficacy revealed by single-cell analysis of antiviral therapeutics Document date: 2019_4_12
ID: aiyg061l_12
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/606715 doi: bioRxiv preprint 8 A major advantage of the single-cell platform is that the effect of a drug on the viable 117 population can be determined. To analyze the single-cell data, we use five phenomenological 118 parameters extracted from each time course (Fig. S4c) . These parameters are: maximum 119 fluorescence observed, .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/606715 doi: bioRxiv preprint 8 A major advantage of the single-cell platform is that the effect of a drug on the viable 117 population can be determined. To analyze the single-cell data, we use five phenomenological 118 parameters extracted from each time course (Fig. S4c) . These parameters are: maximum 119 fluorescence observed, which correlates to yield of genomic RNA; slope at the time of half-120 maximum fluorescence, which correlates to replication speed; infection time, which, to a first 121 approximation, is the time it takes for an infection to go from start to finish akin to the virus was most sensitive to 2'-C-Me-A was unexpected but could be easily rationalized by the notion 140 All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- genomic rna and single cell: 1, 2, 3, 4, 5, 6
- genomic rna and time course: 1, 2, 3, 4, 5, 6, 7
- genomic rna yield and time course: 1
- infection time and major advantage: 1
- infection time and single cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- infection time and time course: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- observe fluorescence and single cell: 1
- observe fluorescence and time course: 1
Co phrase search for related documents, hyperlinks ordered by date