Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_24
Snippet: Our work further quantified the complex role that antibody profiles play in future immune responses to influenza. We confirmed the prominent role of pre-existing, homologous titers in determining the risk of seroconversion. However, we found that participants who had higher immunity to previously exposed strains were more likely to experience seroconversion to recent strains after adjusting for homologous titer. These findings were not affected b.....
Document: Our work further quantified the complex role that antibody profiles play in future immune responses to influenza. We confirmed the prominent role of pre-existing, homologous titers in determining the risk of seroconversion. However, we found that participants who had higher immunity to previously exposed strains were more likely to experience seroconversion to recent strains after adjusting for homologous titer. These findings were not affected by age or selfreported vaccination (figs. S9 and S10 and tables S7 to S9). Given individuals with high immunity to non-recent strains tended to have higher homologous titers (fig. S11 and table S10 and S11), we investigated whether the effect of immunity to non-recent strains was mediated by homologous titer (figs. S12 and S13; detailed in Materials and Methods) and found that preexisting immunity to non-recent strains imposes a positive direct effect on the risk of seroconversion to recent strains but a negative, homologous titer mediated, indirect effect (figs. S12 and S13; detailed in Materials and Methods).
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