Author: Hasan Ahmad, Syed; Smith, Richard; Camilleri, Brian
Title: Belatacept, kidney transplantation and COVIDâ€19: successful management of the first reported case within the United Kingdom Cord-id: hg0kk6qu Document date: 2020_6_30
ID: hg0kk6qu
Snippet: Kidney transplant recipients may be at particular risk of acquiring SARSâ€CoVâ€2 infection with poor outcomes.(1) In a recent case report (2) it was hypothesised that kidney transplant recipients on maintenance belatacept, a cytotoxic Tâ€lymphocyteâ€associated protein 4 (CTLAâ€4) fusion protein, have a milder disease course due to belatacept mitigating the cytokine storm and resultant acute respiratory distress syndrome which have been linked to severity of COVIDâ€19. (3) Here we present t
Document: Kidney transplant recipients may be at particular risk of acquiring SARSâ€CoVâ€2 infection with poor outcomes.(1) In a recent case report (2) it was hypothesised that kidney transplant recipients on maintenance belatacept, a cytotoxic Tâ€lymphocyteâ€associated protein 4 (CTLAâ€4) fusion protein, have a milder disease course due to belatacept mitigating the cytokine storm and resultant acute respiratory distress syndrome which have been linked to severity of COVIDâ€19. (3) Here we present the first reported case in the United Kingdom of a kidney transplant patient on belatacept who on the contrary developed a severe COVIDâ€19 pneumonia requiring intensive care admission and intubation.
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