Author: Kwang Su Kim; Keisuke Ejima; Yusuke Ito; Shoya Iwanami; Hirofumi Ohashi; Yoshiki Koizumi; Yusuke Asai; Shinji Nakaoka; Koichi Watashi; Robin N Thompson; Shingo Iwami
Title: Modelling SARS-CoV-2 Dynamics: Implications for Therapy Document date: 2020_3_27
ID: 09r4d3nu_5
Snippet: To extend our analysis to include SARS-CoV, we analysed SARS-CoV viral 111 loads in nasopharyngeal aspirate reported by Peiris et al. (12) and MERS-CoV viral 112 loads reported by Oh et al. (8) in sputum or tracheal aspirate. The estimated 113 parameters, viral load at symptom onset, and the indices derived from the estimated 114 parameters are listed in Table 1 and from bootstrap t-test) (Fig. 2) . This demonstrates that in vivo viral dynamics o.....
Document: To extend our analysis to include SARS-CoV, we analysed SARS-CoV viral 111 loads in nasopharyngeal aspirate reported by Peiris et al. (12) and MERS-CoV viral 112 loads reported by Oh et al. (8) in sputum or tracheal aspirate. The estimated 113 parameters, viral load at symptom onset, and the indices derived from the estimated 114 parameters are listed in Table 1 and from bootstrap t-test) (Fig. 2) . This demonstrates that in vivo viral dynamics of 121 SARS-CoV infection are similar to those for MERS-CoV in mild cases but not in 122 severe cases. Collectively, the findings from the viral load data analyses for the two 123 different specimens (throat/nasal swabs and nasopharyngeal/sputum/tracheal 124 aspirate) implied that SARS-CoV-2 also causes infection more effectively than 125
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