Author: Islam, Ovinu Kibria; Alâ€Emran, Hassan M.; Hasan, Md. Shazid; Anwar, Azraf; Jahid, Md. Iqbal Kabir; Hossain, M. Anwar
Title: Emergence of European and North American mutant variants of SARSâ€CoVâ€2 in Southeast Asia Cord-id: ze33iu2v Document date: 2020_7_23
ID: ze33iu2v
Snippet: The SARSâ€CoVâ€2 coronavirus is responsible for the current COVIDâ€19 pandemic, with an ongoing toll of over 5 million infections and 333 thousand deaths worldwide within the first 5 months. Insight into the phylodynamics and mutation variants of this virus is vital to understanding the nature of its spread in different climate conditions. The incidence rate of COVIDâ€19 is increasing at an alarming pace within subtropical Southeast Asian nations with high temperatures and humidity. To under
Document: The SARSâ€CoVâ€2 coronavirus is responsible for the current COVIDâ€19 pandemic, with an ongoing toll of over 5 million infections and 333 thousand deaths worldwide within the first 5 months. Insight into the phylodynamics and mutation variants of this virus is vital to understanding the nature of its spread in different climate conditions. The incidence rate of COVIDâ€19 is increasing at an alarming pace within subtropical Southeast Asian nations with high temperatures and humidity. To understand this spread, we analyzed 444 genome sequences of SARSâ€CoVâ€2 available on the GISAID platform from 6 Southeast Asian countries. Multiple sequence alignments and maximum likelihood phylogenetic analyses were performed to analyze and characterize the nonâ€synonymous mutant variants circulating in this region. Global mutation distribution analysis showed that the majority of the mutations found in this region are also prevalent in Europe and North America, and the concurrent presence of these mutations at a high frequency in other countries indicate possible transmission routes. Unique spike protein and nonâ€structural protein mutations were observed circulating within confined area of a given country. We divided the circulating viral strains into 4 major groups and 3 subâ€groups on the basis of the most frequent nonâ€synonymous (NS) mutations. Strains with a unique set of 4 coâ€evolving mutations were found to be circulating at a high frequency within India, specifically. Group 2 strains characterized by two coâ€evolving NS mutants which alter in RdRp (P323L) and spike (S) protein (D614G), were found to be common in Europe and North America. These European and North American variants have rapidly emerged as dominant strains within Southeast Asia, increasing from a 0% prevalence in January to an 81% by May 2020. These variants may have an evolutionary advantage over their ancestral types and could present a large threat to Southeast Asia for the coming winter.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date