Author: Kwang Su Kim; Keisuke Ejima; Yusuke Ito; Shoya Iwanami; Hirofumi Ohashi; Yoshiki Koizumi; Yusuke Asai; Shinji Nakaoka; Koichi Watashi; Robin N Thompson; Shingo Iwami
Title: Modelling SARS-CoV-2 Dynamics: Implications for Therapy Document date: 2020_3_27
ID: 09r4d3nu_12
Snippet: The majority of antiviral drugs inhibit intracellular virus replication. Although 159 their antiviral efficacies need to be confirmed, lopinavir/ritonavir (HIV protease 160 inhibitors), remdesivir (anti-Ebola virus disease candidate) and other nucleoside 161 analogues, and interferon have the potential to suppress SARS-CoV-2 by blocking 162 virus production (15, 16) . Interestingly, our results suggest that, even for relatively 163 small inhibiti.....
Document: The majority of antiviral drugs inhibit intracellular virus replication. Although 159 their antiviral efficacies need to be confirmed, lopinavir/ritonavir (HIV protease 160 inhibitors), remdesivir (anti-Ebola virus disease candidate) and other nucleoside 161 analogues, and interferon have the potential to suppress SARS-CoV-2 by blocking 162 virus production (15, 16) . Interestingly, our results suggest that, even for relatively 163 small inhibition rates of around 30%, the AUC of viral load is partially reduced if 164 therapy is initiated early (within three days after symptom onset) (Fig. 3BE) . 165
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