Author: Bryce, Clare; Grimes, Zachary; Pujadas, Elisabet; Ahuja, Sadhna; Beasley, Mary Beth; Albrecht, Randy; Hernandez, Tahyna; Stock, Aryeh; Zhao, Zhen; AlRasheed, Mohamed Rizwan; Chen, Joyce; Li, Li; Wang, Diane; Corben, Adriana; Haines, G. Kenneth; Westra, William H.; Umphlett, Melissa; Gordon, Ronald E.; Reidy, Jason; Petersen, Bruce; Salem, Fadi; Fiel, Maria Isabel; El Jamal, Siraj M.; Tsankova, Nadejda M.; Houldsworth, Jane; Mussa, Zarmeen; Veremis, Brandon; Sordillo, Emilia; Gitman, Melissa R.; Nowak, Michael; Brody, Rachel; Harpaz, Noam; Merad, Miriam; Gnjatic, Sacha; Liu, Wen-Chun; Schotsaert, Michael; Miorin, Lisa; Aydillo Gomez, Teresa A.; Ramos-Lopez, Irene; Garcia-Sastre, Adolfo; Donnelly, Ryan; Seigler, Patricia; Keys, Calvin; Cameron, Jennifer; Moultrie, Isaiah; Washington, Kae-Lynn; Treatman, Jacquelyn; Sebra, Robert; Jhang, Jeffrey; Firpo, Adolfo; Lednicky, John; Paniz-Mondolfi, Alberto; Cordon-Cardo, Carlos; Fowkes, Mary E.
Title: Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience Cord-id: z32o3ufh Document date: 2021_4_1
ID: z32o3ufh
Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe and disproportionately affected New York City between March and May 2020. Here, we report on the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City. Autopsies revealed large pulmonary emboli in six cases. Diffuse alveolar damage was present in over 90% of cases. We also report microth
Document: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe and disproportionately affected New York City between March and May 2020. Here, we report on the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City. Autopsies revealed large pulmonary emboli in six cases. Diffuse alveolar damage was present in over 90% of cases. We also report microthrombi in multiple organ systems including the brain, as well as hemophagocytosis. We additionally provide electron microscopic evidence of the presence of the virus in our samples. Laboratory results of our COVID-19 cohort disclose elevated inflammatory markers, abnormal coagulation values, and elevated cytokines IL-6, IL-8, and TNFα. Our autopsy series of COVID-19-positive patients reveals that this disease, often conceptualized as a primarily respiratory viral illness, has widespread effects in the body including hypercoagulability, a hyperinflammatory state, and endothelial dysfunction. Targeting of these multisystemic pathways could lead to new treatment avenues as well as combination therapies against SARS-CoV-2 infection.
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