Author: Sun, Haiying; Ning, Ruoqi; Tao, Yu; Yu, Chong; Deng, Xiaoyan; Zhao, Caili; Meng, Silu; Tang, Fangxu; Xu, Dong
Title: Risk Factors for Mortality in 244 Older Adults With COVIDâ€19 in Wuhan, China: A Retrospective Study Cord-id: gnx3t5gw Document date: 2020_5_12
ID: gnx3t5gw
Snippet: BACKGROUND/OBJECTIVES: Previous studies have reported that older patients may experience worse outcome(s) after infection with severe acute respiratory syndrome coronavirusâ€2 than younger individuals. This study aimed to identify potential risk factors for mortality in older patients with coronavirus disease 2019 (COVIDâ€19) on admission, which may help identify those with poor prognosis at an early stage. DESIGN: Retrospective caseâ€control. SETTING: Fever ward of Sinoâ€French New City Bra
Document: BACKGROUND/OBJECTIVES: Previous studies have reported that older patients may experience worse outcome(s) after infection with severe acute respiratory syndrome coronavirusâ€2 than younger individuals. This study aimed to identify potential risk factors for mortality in older patients with coronavirus disease 2019 (COVIDâ€19) on admission, which may help identify those with poor prognosis at an early stage. DESIGN: Retrospective caseâ€control. SETTING: Fever ward of Sinoâ€French New City Branch of Tongji Hospital, Wuhan, China. PARTICIPANTS: Patients aged 60 years or older with COVIDâ€19 (n = 244) were included, of whom 123 were discharged and 121 died in hospital. MEASUREMENTS: Data retrieved from electronic medical records regarding symptoms, signs, and laboratory findings on admission, and final outcomes of all older patients with COVIDâ€19, were retrospectively reviewed. Univariate and multivariate logistic regression analyses were used to explore risk factors for death. RESULTS: Univariate analysis revealed that several clinical characteristics and laboratory variables were significantly different (ie, P < .05) between discharged and deceased patients. Multivariable logistic regression analysis revealed that lymphocyte (LYM) count (odds ratio [OR] = 0.009; 95% confidence interval [CI] = 0.001â€0.138; P = .001) and older age (OR = 1.122; 95% CI = 1.007â€1.249; P = .037) were independently associated with hospital mortality. White blood cell count was also an important risk factor (P = .052). The area under the receiver operating characteristic curve in the logistic regression model was 0.913. Risk factors for inâ€hospital death were similar between older men and women. CONCLUSION: Older age and lower LYM count on admission were associated with death in hospitalized COVIDâ€19 patients. Stringent monitoring and early intervention are needed to reduce mortality in these patients.
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