Author: Elie, B.; Lecorche, E.; Sofonea, M. T.; Trombert, S.; Foulogne, V.; Guedj, J.; Haim-Boukobza, S.; Roquebert, B.; Alizon, S.
Title: Inferring SARS-CoV-2 variant within-host kinetics Cord-id: gpj24dwc Document date: 2021_5_29
ID: gpj24dwc
Snippet: SARS-CoV-2 variants are causing epidemic rebounds in many countries. By analyzing longitudinal cycle threshold (Ct) values from screening tests in the general population and hospitals, we find that infections caused by variant lineages have higher peak viral load than wild type lineages and, for the B.1.1.7 lineage, have a longer infectious period duration. Linking within-host kinetics to transmission data suggests that infections caused by variants have higher transmission potentials and that t
Document: SARS-CoV-2 variants are causing epidemic rebounds in many countries. By analyzing longitudinal cycle threshold (Ct) values from screening tests in the general population and hospitals, we find that infections caused by variant lineages have higher peak viral load than wild type lineages and, for the B.1.1.7 lineage, have a longer infectious period duration. Linking within-host kinetics to transmission data suggests that infections caused by variants have higher transmission potentials and that their epidemiological fitness may depend on the demography of the host population.
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