Selected article for: "cc line and mouse line"
Author: Jessica A. Plante; Kenneth S. Plante; Lisa E. Gralinski; Anne Beall; Martin T. Ferris; Daniel Bottomly; Richard Green; Shannon K. McWeeney; Mark T. Heise; Ralph S. Baric; Vineet D. Menachery
Title: Mucin 4 Protects Female Mice from Coronavirus Pathogenesis
  • Document date: 2020_2_20
    • ID: 99sbhbuo_2
    Snippet: within Mus musculus, and that diversity is distributed evenly throughout the genome, with 32 elevated minor allele frequencies compared to standard natural populations (Aylor et al., 2011; 33 Yang et al., 2007; Yang et al., 2009; Yang et al., 2011 ). Our initial screen within an incompletely 34 inbred set of CC mice (the preCC screen) (Gralinski et al., 2015) , along with an F2 screen 35 utilizing a highly resistant and highly susceptible CC mous.....
    Document: within Mus musculus, and that diversity is distributed evenly throughout the genome, with 32 elevated minor allele frequencies compared to standard natural populations (Aylor et al., 2011; 33 Yang et al., 2007; Yang et al., 2009; Yang et al., 2011 ). Our initial screen within an incompletely 34 inbred set of CC mice (the preCC screen) (Gralinski et al., 2015) , along with an F2 screen 35 utilizing a highly resistant and highly susceptible CC mouse line (Gralinski et al., 2017) , 36 identified nine quantitative trait loci (QTLs) impacting SARS-CoV disease. Among these QTLs 37 was locus HrS2 on chromosome 16, which was identified as modulating SARS-CoV titer levels 38 in the lung (Gralinski et al., 2015) . 39

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