Selected article for: "downstream inhibit and IFN inhibit"
Author: Diamond, Michael S.; Farzan, Michael
Title: The broad-spectrum antiviral functions of IFIT and IFITM proteins
  • Cord-id: jnubcn94
  • Document date: 2012_12_14
    • ID: jnubcn94
    Snippet: Over the past few years, several groups have identified novel genes downstream of type I interferon (IFN) signaling that inhibit infection by individual or multiple families of viruses. Among these IFN stimulated genes (ISGs) with antiviral activity are two genetically and functionally distinct families — IFN-induced proteins with tetratricopeptide repeats (IFIT) and IFN-induced transmembrane proteins (IFITM). This review focuses on recent advances in identifying the unique mechanisms of actio
    Document: Over the past few years, several groups have identified novel genes downstream of type I interferon (IFN) signaling that inhibit infection by individual or multiple families of viruses. Among these IFN stimulated genes (ISGs) with antiviral activity are two genetically and functionally distinct families — IFN-induced proteins with tetratricopeptide repeats (IFIT) and IFN-induced transmembrane proteins (IFITM). This review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM genes, which explain their broad-spectrum activity against replication, spread, and disease pathogenesis of a range of human viruses.

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