Author: La Torre, Francesco; Leonardi, Lucia; Giardino, Giuliana; Volpi, Stefano; Federici, Silvia; Soresina, Annarosa; Cancrini, Caterina; Lougaris, Vassilios; Castagnoli, Riccardo; Corrente, Stefania; Cardinale, Fabio
Title: Immunological basis of virusâ€host interaction in COVIDâ€19 Cord-id: gsghl859 Document date: 2020_11_24
ID: gsghl859
Snippet: COVIDâ€19 is a complex new viral disease, in which a strict balance between antiâ€viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, ageâ€related susceptibi
Document: COVIDâ€19 is a complex new viral disease, in which a strict balance between antiâ€viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, ageâ€related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVIDâ€19.
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