Selected article for: "average number and total number"
Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways
  • Document date: 2019_5_24
    • ID: cbit5xci_43
    Snippet: We then investigated how the surfaces of the unmodified and IAA-modified nanoparticles changed after exposure to serum proteins ex vivo. Mass spectrometry-based proteomic analysis revealed that IAA modification of bPEI and chitosan significantly decreased complement adsorption that typically occurs after incubation in mouse plasma for one hour (Supplementary Fig. 7A-C) . Exclusively with the bPEI nanoparticles, IAA modification significantly decr.....
    Document: We then investigated how the surfaces of the unmodified and IAA-modified nanoparticles changed after exposure to serum proteins ex vivo. Mass spectrometry-based proteomic analysis revealed that IAA modification of bPEI and chitosan significantly decreased complement adsorption that typically occurs after incubation in mouse plasma for one hour (Supplementary Fig. 7A-C) . Exclusively with the bPEI nanoparticles, IAA modification significantly decreased the adsorption of fibrinogen proteins to the nanoparticle surface ( Supplementary Fig. 7D-F) . These data suggest that the evolution of the protein corona is dependent on both the type of polymer (e.g., chitosan, bPEI) and if the polymer is modified with IAA.

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