Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways Document date: 2019_5_24
ID: cbit5xci_62
Snippet: Fibrinogen can enhance innate immune activation and upregulate chemokine expression [46] , which was observed after treatment with unmodified PEI nanoparticles but not IAA-modified PEI nanoparticles. The reduced toxicity could not be attributed to changes in complement activation, blood hemolysis, or anaphylactic responses mediated by histamine......
Document: Fibrinogen can enhance innate immune activation and upregulate chemokine expression [46] , which was observed after treatment with unmodified PEI nanoparticles but not IAA-modified PEI nanoparticles. The reduced toxicity could not be attributed to changes in complement activation, blood hemolysis, or anaphylactic responses mediated by histamine.
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