Selected article for: "cancer type and novel function"

Author: Rizzi, Romeo; Mahata, Pritha; Mathieson, Luke; Moscato, Pablo
Title: Hierarchical Clustering Using the Arithmetic-Harmonic Cut: Complexity and Experiments
  • Cord-id: jn3aqdck
  • Document date: 2010_12_2
  • ID: jn3aqdck
    Snippet: Clustering, particularly hierarchical clustering, is an important method for understanding and analysing data across a wide variety of knowledge domains with notable utility in systems where the data can be classified in an evolutionary context. This paper introduces a new hierarchical clustering problem defined by a novel objective function we call the arithmetic-harmonic cut. We show that the problem of finding such a cut is [Image: see text]-hard and [Image: see text]-hard but is fixed-parame
    Document: Clustering, particularly hierarchical clustering, is an important method for understanding and analysing data across a wide variety of knowledge domains with notable utility in systems where the data can be classified in an evolutionary context. This paper introduces a new hierarchical clustering problem defined by a novel objective function we call the arithmetic-harmonic cut. We show that the problem of finding such a cut is [Image: see text]-hard and [Image: see text]-hard but is fixed-parameter tractable, which indicates that although the problem is unlikely to have a polynomial time algorithm (even for approximation), exact parameterized and local search based techniques may produce workable algorithms. To this end, we implement a memetic algorithm for the problem and demonstrate the effectiveness of the arithmetic-harmonic cut on a number of datasets including a cancer type dataset and a corona virus dataset. We show favorable performance compared to currently used hierarchical clustering techniques such as [Image: see text]-Means, Graclus and Normalized-Cut. The arithmetic-harmonic cut metric overcoming difficulties other hierarchal methods have in representing both intercluster differences and intracluster similarities.

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