Author: Killerby, Marie E; Ata Ur Rasheed, Mohammad; Tamin, Azaibi; Harcourt, Jennifer L; Abedi, Glen R; Lu, Xiaoyan; Kujawski, Stephanie; Shah, Melisa M; Kirking, Hannah L; Gold, Jeremy A W; Salvatore, Phillip P; Coughlin, Melissa M; Whitaker, Brett; Tate, Jacqueline E; Watson, John T; Lindstrom, Stephen; Hall, Aron J; Fry, Alicia M; Gerber, Susan I; Midgley, Claire M; Thornburg, Natalie J
Title: Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of COVID-19 in the United States Cord-id: yikh7pm5 Document date: 2021_3_7
ID: yikh7pm5
Snippet: We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to six months post-onset, among 14 early US COVID-19 patients. We isolated viable SARS-CoV-2 from rRT-PCR-positive respiratory specimens collected during days 0-8 post-onset, but not after. All 13 patients with two or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of neutralizing
Document: We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to six months post-onset, among 14 early US COVID-19 patients. We isolated viable SARS-CoV-2 from rRT-PCR-positive respiratory specimens collected during days 0-8 post-onset, but not after. All 13 patients with two or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of neutralizing antibodies. Eight participants provided serum at six months post-onset; all retained detectable anti-spike IgG, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at six months.
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