White blood count, D‐dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID‐19 patients: The French multicenter CLOTVID retrospective study

Galland, Joris; Thoreau, Benjamin; Delrue, Maxime; Neuwirth, Marie; Stepanian, Alain; Chauvin, Anthony; Dellal, Azeddine; Nallet, Olivier; Roriz, Melanie; Devaux, Mathilde; London, Jonathan; Martin‐Lecamp, Gonzague; Froissart, Antoine; Arab, Nouara; Ferron, Bertrand; Groff, Marie‐Helene; Queyrel, Viviane; Lorut, Christine; Regard, Lucile; Berthoux, Emilie; Bayer, Guillaume; Comarmond, Chloe; Lioger, Bertrand; Mekinian, Arsène; Szwebel, Tali‐Anne; Sené, Thomas; Amador‐Boreiro, Blanca; Mangin, Olivier; Sellier, Pierre‐Olivier; Mouly, Stephane; Kevorkian, Jean‐Philippe; Siguret, Virginie; Vodovar, Dominique; Sene, Damien; Mathieu, Albertini; Sara, Bouajila; Kimbimbi, Britany; Ruxandra, Burlacu; Léa, Cacoub; Karine, Champion; Véronique, Delcey; Jean‐Guillaume, Dillinger; Florine, Feron; Aline, Frazier; Funck‐Bretano, Thomas; Diane‐Cecile, Gauthier; Jean‐François, Gautier; Patrick, Henry; Tessa, Huscenot; Izabel, Sarah; Jaulerry, Mathilde; Moenes, Jouabli; Jean‐Baptiste, Julla; Marie, Laloi Michelin; Pierre, Leroy; Amanda, Lopes; Bruno, Megarbane; Maxime, Michon; Anne‐Lise, Munier; Yoram, Nahmani; Martin, Nicol; Eroan, Nicolas; Audrey, Poulat; Eric, Revue; Pascal, Richette; Jean‐Pierre, Riveline; Emma, Rubenstein; Adrien, Zanin; Clément, Aveneau; Paul, Bastard; Diane, Beauvais; Loredana, Boghez; Alix, Borderiou; Paul, Conway; Lavignia, Cosma; Vincent, Davy; Clément, Desjardin; Sandra, Devatine; Christel, Ducroz Gerardin; Charlotte, Dupe; Chloé, Gobert; Clotilde, Gros; Soumaya, Kadiri; Enmat, Khan; Sandrine, Ongnessek; Fatima, Rhmari; Isabelle, Sacco; Natalia, Saptefrat; Pauline, Schaupp; Justine, Serre; Georgios, Sideris; Sonia, Smati; Marine, Tournier; Pauline, Treca; Tony, Truong; Mathilde, Tuffier; Mattéo, Arcelli; Yvonnick, Boue; Alban, Copie; Nicolas, Deye; Jean‐Michel, Ekherian; Zaccaria, Errabih; Antoine, Gonde; Caroline, Grant; Emmanuelle, Guerin; Adèle, Magalhaes; Isabelle, Malissin; Edouard, Meurisse; Aymen, Mrad; Giulia, Naim; Philippe, Nguyen; Kiyoko, Nitenberg; Adrien, Pepin‐Lehalleur; Arthur, Perault; Lucile, Perrin; Maxime, Renaud; Laetitia, Sutterlin; Maxime, Delrue; Virginie, Siguret; Alain, Stepanian

BACKGROUND: A high prevalence of pulmonary embolism (PE) has been described during COVID‐19. Our aim was to identify predictive factors of PE in non‐ICU hospitalized COVID‐19 patients. METHODS: Data and outcomes were collected upon admission during a French multicenter retrospective study, including patients hospitalized for COVID‐19, with a CT pulmonary angiography (CTPA) performed in the emergency department for suspected PE. Predictive factors significantly associated with PE were identified through a multivariate regression model. RESULTS: A total of 88 patients (median [IQR] age of 68 years [60‐78]) were analyzed. Based on CTPA, 47 (53.4%) patients were diagnosed with PE, and 41 were not. D‐dimer ≥3000 ng/mL (OR 8.2 [95% CI] 1.3‐74.2, sensitivity (Se) 0.84, specificity (Sp) 0.78, P = .03), white blood count (WBC) ≥12.0 G/L (29.5 [2.3‐1221.2], Se 0.47, Sp 0.92, P = .02), and ferritin ≥480 µg/L (17.0 [1.7‐553.3], Se 0.96, Sp 0.44, P = .03) were independently associated with the PE diagnosis. The presence of the double criterion D‐dimer ≥3000 ng/mL and WBC ≥12.0 G/L was greatly associated with PE (OR 21.4 [4.0‐397.9], P = .004). CONCLUSION: The white blood count, the D‐dimer and ferritin levels could be used as an indication for CTPA to confirm PE on admission in non‐ICU COVID‐19 patients.