Selected article for: "complex form and protease activity"
Author: Sarah Krieg; Fabian Pott; Laura Eckei; Maud Verheirstraeten; Mareike Bütepage; Barbara Lippok; Christine Goffinet; Bernhard Lüscher; Patricia Verheugd
Title: Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2
  • Document date: 2020_1_8
    • ID: 2vecg9op_1
    Snippet: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.07.896977 doi: bioRxiv preprint 6 CHIKV encodes a non-structural polyprotein (nsP) that is translated early after infection. This 120 protein is then cleaved into the 4 individual nsP1-4 that together form a functional replication 121 complex. The processi.....
    Document: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.07.896977 doi: bioRxiv preprint 6 CHIKV encodes a non-structural polyprotein (nsP) that is translated early after infection. This 120 protein is then cleaved into the 4 individual nsP1-4 that together form a functional replication 121 complex. The processing occurs auto-catalytically through the protease that is part of nsP2 122 [43] . Mutations interfering with protease activity result in defective CHIKV replication [44] . 123

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