Author: Sarah Krieg; Fabian Pott; Laura Eckei; Maud Verheirstraeten; Mareike Bütepage; Barbara Lippok; Christine Goffinet; Bernhard Lüscher; Patricia Verheugd
Title: Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2 Document date: 2020_1_8
ID: 2vecg9op_17
Snippet: MARylation by ARTD10cat efficiently repressed nsP2-459-798 protease activity, which was 315 antagonized by nsP3 or the isolated macrodomain (Fig. 5e,f) . Thus, these findings demonstrate 316 that the nsP2 protease domain is reversibly inhibited by MARylation and support our initial 317 hypothesis that MARylation inhibits polyprotein processing. We provide a mechanism how 318 MARylation antagonizes and consequently how the nsP3 macrodomain contrib.....
Document: MARylation by ARTD10cat efficiently repressed nsP2-459-798 protease activity, which was 315 antagonized by nsP3 or the isolated macrodomain (Fig. 5e,f) . Thus, these findings demonstrate 316 that the nsP2 protease domain is reversibly inhibited by MARylation and support our initial 317 hypothesis that MARylation inhibits polyprotein processing. We provide a mechanism how 318 MARylation antagonizes and consequently how the nsP3 macrodomain contributes to CHIKV 319 replication. 320 321 Discussion 322
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