Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV Document date: 2020_3_2
ID: jmrg4oeb_16
Snippet: Our study also revealed that the 2019-nCoV has a unique four amino acid insertion 15 (681-PRRA-684) within the spike protein, or within nucleotide position 23,619-23,632 ( Fig 4C) . Interestingly, such an insertion (PRRA) within the spike protein of 2019-nCoV creates a potential cleavage site RRAR for the mammalian furin protein, which the consensus sequence is RXXR. The potential furin or TMPRSS2 cleavage site is inserted at the boundary betwe.....
Document: Our study also revealed that the 2019-nCoV has a unique four amino acid insertion 15 (681-PRRA-684) within the spike protein, or within nucleotide position 23,619-23,632 ( Fig 4C) . Interestingly, such an insertion (PRRA) within the spike protein of 2019-nCoV creates a potential cleavage site RRAR for the mammalian furin protein, which the consensus sequence is RXXR. The potential furin or TMPRSS2 cleavage site is inserted at the boundary between the S1 and S2 domains of the spike protein, and the first proline 20 residue of the PRRA insertion may introduce a beta turn into the polypeptide chain. To understand the uniqueness of this insertion, we performed sequence comparison using represented SARS-CoV strains from human, civet and bat. Our study showed that this author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- amino acid and beta turn: 1
- amino acid and cleavage site: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- amino acid and consensus sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- amino acid and furin protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- amino acid and nucleotide position: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- amino acid and polypeptide chain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- amino acid and potential furin: 1, 2, 3, 4, 5, 6
- amino acid and PRRA insertion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- amino acid insertion and cleavage site: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- amino acid insertion and consensus sequence: 1
- amino acid insertion and furin protein: 1, 2, 3, 4, 5
- amino acid insertion and nucleotide position: 1
- amino acid insertion and potential furin: 1, 2
- amino acid insertion and PRRA insertion: 1, 2, 3, 4, 5, 6, 7, 8, 9
- bat civet and cleavage site: 1
- bat civet and furin protein: 1
- beta turn and cleavage site: 1
- beta turn and furin protein: 1
- cleavage site and PRRA insertion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
Co phrase search for related documents, hyperlinks ordered by date