Author: Zhu, Linnan; Yang, Penghui; Zhao, Yingze; Zhuang, Zhenkun; Wang, Zhifeng; Song, Rui; Zhang, Jie; Liu, Chuanyu; Gao, Qianqian; Xu, Qumiao; Wei, Xiaoyu; Sun, Hai-Xi; Ye, Beiwei; Wu, Yanan; Zhang, Ning; Lei, Guanglin; Yu, Linxiang; Yan, Jin; Diao, Guanghao; Meng, Fanping; Bai, Changqing; Mao, Panyong; Yu, Yeya; Wang, Mingyue; Yuan, Yue; Deng, Qiuting; Li, Ziyi; Huang, Yunting; Hu, Guohai; Liu, Yang; Wang, Xiaoqian; Xu, Ziqian; Liu, Peipei; Bi, Yuhai; Shi, Yi; Zhang, Shaogeng; Chen, Zhihai; Wang, Jian; Xu, Xun; Wu, Guizhen; Wang, Fusheng; Gao, George F.; Liu, Longqi; Liu, William J.
Title: Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients Cord-id: zk8z8z4i Document date: 2020_7_19
ID: zk8z8z4i
Snippet: SUMMARY COVID-19 is a severe infectious disease that is a current global health threat. However, little is known about its hallmarks compared to other infectious diseases. Here, we report the single-cell transcriptional landscape of longitudinally collected peripheral blood mononuclear cells (PBMCs) in both COVID-19 and influenza A virus (IAV)-infected patients. We observed increase of plasma cells in both COVID-19 and IAV patients, and XAF1-, TNF- and FAS-induced T cell apoptosis in COVID-19 pa
Document: SUMMARY COVID-19 is a severe infectious disease that is a current global health threat. However, little is known about its hallmarks compared to other infectious diseases. Here, we report the single-cell transcriptional landscape of longitudinally collected peripheral blood mononuclear cells (PBMCs) in both COVID-19 and influenza A virus (IAV)-infected patients. We observed increase of plasma cells in both COVID-19 and IAV patients, and XAF1-, TNF- and FAS-induced T cell apoptosis in COVID-19 patients. Further analyses revealed distinct signaling pathways activated in COVID-19 (STAT1 and IRF3) vs. IAV (STAT3 and NFκB) patients and substantial differences in the expression of key factors. These factors include relatively increase of IL6R and IL6ST expression in COVID-19 patients, but similarly increased IL-6 concentrations compared to IAV patients, supporting the clinical observations of increased pro-inflammatory cytokines in COVID-19 patients. Thus, we provide the landscape of PBMCs and unveil distinct immune response pathways in COVID-19 and IAV patients.
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