Loss of IKK subunits limits NF-?B signaling in reovirus infected cells

Andrew J. McNamara; Pranav Danthi

The mammalian innate immune response is an effective response to viral intrusion. The primary mechanism of innate control of virus infection is the production of antiviral 9 of uninfected cells treated with TNFα, using the same criteria described above, led to 150 the upregulation of 32 transcripts ( Fig. 2A) . In contrast, TNFα has no significant effect 151 on gene expression in cells infected with T3A ( Fig. 2B, 2C, 2D ). These data indicate 152 that infection of cells with T3A results in blockade of NF-κB-dependent transcription. 153 vgRNA and TNFα initiate NF-κB signaling via distinct routes. Therefore, our analyses 154 suggest that reovirus blocks NF-κB signaling at a step that is shared by both signaling 155 pathways. 156