Author: Hasler, Fabio; Duda, Agathe; Kündig, Thomas M.; Johansen, Pål
Title: A tissue culture infectious dose (TCID)-derived protocol for testing of SARS-CoV-2 neutralization of serum antibodies on adherent cells Cord-id: egx5ulbe Document date: 2021_8_27
ID: egx5ulbe
Snippet: For a cytopathic virus such as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the neutralization capacity of serum from convalescent or vaccinated persons or of therapeutic antibodies can be tested on adherent cell cultures. Here, a simple and tissue culture infectious dose (TCID)-derived protocol for assessment of neutralization of SARS-CoV-2 is described. Compared to the often applied plaque-forming unit (PFU) assay, the working load is lower, and fewer manipulations of the
Document: For a cytopathic virus such as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the neutralization capacity of serum from convalescent or vaccinated persons or of therapeutic antibodies can be tested on adherent cell cultures. Here, a simple and tissue culture infectious dose (TCID)-derived protocol for assessment of neutralization of SARS-CoV-2 is described. Compared to the often applied plaque-forming unit (PFU) assay, the working load is lower, and fewer manipulations of the infected cultures are required. Hence, the method is safer for the personnel.
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