Author: Alex Perkins; Sean M. Cavany; Sean M Moore; Rachel J Oidtman; Anita Lerch; Marya Poterek
Title: Estimating unobserved SARS-CoV-2 infections in the United States Document date: 2020_3_18
ID: fb8mca1h_1
Snippet: SARS-CoV-2 is a newly emerged coronavirus that is causing a global pandemic (1) . The unprecedented spread of SARS-CoV-2 owes to its high transmissibility (2) , pre-symptomatic transmission (3), and transmission by asymptomatic infections (4) . An appreciable fraction of infections are asymptomatic (5) , and many others result in mild symptoms that could be mistaken for other respiratory illnesses (6) . These factors point to a potentially large .....
Document: SARS-CoV-2 is a newly emerged coronavirus that is causing a global pandemic (1) . The unprecedented spread of SARS-CoV-2 owes to its high transmissibility (2) , pre-symptomatic transmission (3), and transmission by asymptomatic infections (4) . An appreciable fraction of infections are asymptomatic (5) , and many others result in mild symptoms that could be mistaken for other respiratory illnesses (6) . These factors point to a potentially large reservoir of unobserved infections (7) , especially in settings where capacity to test for SARS-CoV-2 has been limited (8) . The United States is one such country in which limited testing has been a major concern, particularly as imported cases, and now local cases, have increased over time (9) . Until February 27, testing criteria in the US were limited to close contacts of confirmed cases and those with recent travel to China (9) . This means that any local infections resulting from an unobserved imported infection would have gone unnoticed. Community transmission occurred without notice while testing was still being rolled out (10, 11) , albeit to an unknown extent.
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