Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV Document date: 2020_3_2
ID: jmrg4oeb_23
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10. 1101 /2020 We have also identified a unique four amino acid (PRRA) insertion between S1 and S2 domains of the spike protein, which may function as a furin or TMPRSS2 cleavage site. It has been shown that CoV may undergo a protease cleavage to trigger the viruscell membrane fusion 10,14 . This flexibility in priming and triggering the fusion machinery.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10. 1101 /2020 We have also identified a unique four amino acid (PRRA) insertion between S1 and S2 domains of the spike protein, which may function as a furin or TMPRSS2 cleavage site. It has been shown that CoV may undergo a protease cleavage to trigger the viruscell membrane fusion 10,14 . This flexibility in priming and triggering the fusion machinery greatly modulates the viral pathogenicity and tropism of different coronaviruses 18,19 .
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