Selected article for: "cell receptor host and cleavage site"
Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
  • Document date: 2020_3_2
    • ID: jmrg4oeb_25
    Snippet: However, such protease cleavage has not been detected in SARS-CoV 19 . Introducing a cleavage site into SARS-CoV resulted in spike protein cleavage and potentiated the membrane fusion activity 11 . In addition, introducing a cleaved spike protein into a SARS-CoV pseudotype virus allowed it to directly enter host cells 31 . Based on previous sequencing and structural analysis, the 2019-nCoV spike protein were predicted to 10 interact with the ACE2.....
    Document: However, such protease cleavage has not been detected in SARS-CoV 19 . Introducing a cleavage site into SARS-CoV resulted in spike protein cleavage and potentiated the membrane fusion activity 11 . In addition, introducing a cleaved spike protein into a SARS-CoV pseudotype virus allowed it to directly enter host cells 31 . Based on previous sequencing and structural analysis, the 2019-nCoV spike protein were predicted to 10 interact with the ACE2 receptor to trigger the fusion with the host cell membrane and initiate infection 29 . Therefore, mutations or indels altering the S1-S2 subunits should significantly impact viral infection. We hypothesize that the PRRA insertion may render the spike protein to cleavage process, which triggers the viral fusion event.

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