Selected article for: "cleavage process and host cell"
Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
  • Document date: 2020_3_2
    • ID: jmrg4oeb_25
    Snippet: However, such protease cleavage has not been detected in SARS-CoV 19 . Introducing a cleavage site into SARS-CoV resulted in spike protein cleavage and potentiated the membrane fusion activity 11 . In addition, introducing a cleaved spike protein into a SARS-CoV pseudotype virus allowed it to directly enter host cells 31 . Based on previous sequencing and structural analysis, the 2019-nCoV spike protein were predicted to 10 interact with the ACE2.....
    Document: However, such protease cleavage has not been detected in SARS-CoV 19 . Introducing a cleavage site into SARS-CoV resulted in spike protein cleavage and potentiated the membrane fusion activity 11 . In addition, introducing a cleaved spike protein into a SARS-CoV pseudotype virus allowed it to directly enter host cells 31 . Based on previous sequencing and structural analysis, the 2019-nCoV spike protein were predicted to 10 interact with the ACE2 receptor to trigger the fusion with the host cell membrane and initiate infection 29 . Therefore, mutations or indels altering the S1-S2 subunits should significantly impact viral infection. We hypothesize that the PRRA insertion may render the spike protein to cleavage process, which triggers the viral fusion event.

    Search related documents:
    Co phrase search for related documents
    • cleavage process and host cell membrane: 1
    • cleavage process and host cell membrane fusion: 1
    • cleavage process and protease cleavage: 1, 2, 3, 4, 5
    • cleavage process and protein cleavage: 1, 2, 3, 4, 5, 6, 7, 8
    • cleavage process and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • cleavage process and spike protein: 1, 2, 3, 4, 5, 6
    • cleavage process and spike protein cleavage: 1, 2
    • cleavage process and viral fusion: 1, 2
    • cleavage process and viral infection: 1
    • cleavage process spike protein and host cell: 1, 2
    • cleavage process spike protein and host cell membrane: 1
    • cleavage process spike protein and host cell membrane fusion: 1
    • cleavage process spike protein and protein cleavage: 1, 2
    • cleavage process spike protein and SARS cov: 1, 2
    • cleavage process spike protein and spike protein: 1, 2
    • cleavage process spike protein and spike protein cleavage: 1, 2
    • cleavage process spike protein and viral fusion: 1
    • cleavage site and fusion activity: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • cleavage site and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75