Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_21
Snippet: To confirm these findings, we additionally measured MUC5AC in an alternative sample type, bronchoalveolar lavage (BAL), as subjects in the experimental infection study also underwent bronchoscopy at baseline and day 7 after RV infection. BAL MUC5AC protein was similarly increased in COPD subjects versus healthy non-smokers with no difference observed for MUC5B (Supplementary Fig 3) ......
Document: To confirm these findings, we additionally measured MUC5AC in an alternative sample type, bronchoalveolar lavage (BAL), as subjects in the experimental infection study also underwent bronchoscopy at baseline and day 7 after RV infection. BAL MUC5AC protein was similarly increased in COPD subjects versus healthy non-smokers with no difference observed for MUC5B (Supplementary Fig 3) .
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