Author: Zhou, Nan; Zhang, Yun; Zhang, Jin-Chun; Feng, Ling; Bao, Jin-Ku
Title: The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development Cord-id: 1i1n3gw8 Document date: 2013_12_14
ID: 1i1n3gw8
Snippet: The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another “SARS-like†threat to the world. It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor in
Document: The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another “SARS-like†threat to the world. It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.
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