Author: Jessica A. Plante; Kenneth S. Plante; Lisa E. Gralinski; Anne Beall; Martin T. Ferris; Daniel Bottomly; Richard Green; Shannon K. McWeeney; Mark T. Heise; Ralph S. Baric; Vineet D. Menachery
Title: Mucin 4 Protects Female Mice from Coronavirus Pathogenesis Document date: 2020_2_20
ID: 99sbhbuo_3
Snippet: Here, we narrow the HrS2 locus to a priority candidate gene, mucin 4 (Muc4), via the 40 integration of sequence data from the CC founders (Keane et al., 2011) and RNA expression 41 results from our preCC experiment. Low expression of Muc4 in mice containing the PWK/PhJ 42 allele corresponded with the low SARS-CoV titer associated with the QTL located at locus HrS2. 43.....
Document: Here, we narrow the HrS2 locus to a priority candidate gene, mucin 4 (Muc4), via the 40 integration of sequence data from the CC founders (Keane et al., 2011) and RNA expression 41 results from our preCC experiment. Low expression of Muc4 in mice containing the PWK/PhJ 42 allele corresponded with the low SARS-CoV titer associated with the QTL located at locus HrS2. 43
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