Author: Grzelak, Ludivine; Velay, Aurélie; Madec, Yoann; Gallais, Floriane; Staropoli, Isabelle; Schmidt-Mutter, Catherine; Wendling, Marie-Josée; Meyer, Nicolas; Planchais, Cyril; Rey, David; Mouquet, Hugo; Reix, Nathalie; Glady, Ludovic; Hansmann, Yves; Bruel, Timothée; De Séze, Jérome; Fontanet, Arnaud; Gonzalez, Maria; Schwartz, Olivier; Fafi-Kremer, Samira
Title: Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2 Cord-id: jxqq25r1 Document date: 2021_3_7
ID: jxqq25r1
Snippet: We measured Anti-Spike (S), Nucleoprotein (N) and neutralizing antibodies (NAbs) in sera from 308 RT-qPCR (+) healthcare workers with mild disease, collected at two time-points up to 6 months after symptom onset. At Month 1 (M1), anti-S and N antibody levels were higher in males > 50 years or with a body mass index (BMI) > 25. At M3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and NAbs declined faster in males than in females, indep
Document: We measured Anti-Spike (S), Nucleoprotein (N) and neutralizing antibodies (NAbs) in sera from 308 RT-qPCR (+) healthcare workers with mild disease, collected at two time-points up to 6 months after symptom onset. At Month 1 (M1), anti-S and N antibody levels were higher in males > 50 years or with a body mass index (BMI) > 25. At M3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and NAbs declined faster in males than in females, independently of age and BMI, suggesting an association of sex with evolution of the humoral response.
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