Selected article for: "confidence interval and random effect"
Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
  • Document date: 2020_4_15
    • ID: 5r0u2mmo_23
    Snippet: We identified eighty genetic variants within the ACE2 locus as cis-acting spatial eQTLs that 161 physically modulate the expression of genes PIR (encodes Pirin), CA5BP1 (a pseudogene of 162 CA5B), and CA5B (encodes mitochondrial carbonic anhydrase) in lung tissues (S2 Table) . The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.042002 doi: bioRxiv preprint enhancing CA5B transcription. .....
    Document: We identified eighty genetic variants within the ACE2 locus as cis-acting spatial eQTLs that 161 physically modulate the expression of genes PIR (encodes Pirin), CA5BP1 (a pseudogene of 162 CA5B), and CA5B (encodes mitochondrial carbonic anhydrase) in lung tissues (S2 Table) . The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.042002 doi: bioRxiv preprint enhancing CA5B transcription. These variants occurred in two clusters: 1) within the ACE2 168 gene; and 2) within the CLTRN (TMEM27) genea known homologue of ACE2. Expression 169 of CA5BP1, a pseudogene of CA5B, was also repressed (log2[aFC] -0.21 ± 0.01) by 6 SNPs 170 within the ACE2 locus. Within ACE2 itself there were only control regions for the PIR and 171 CA5B genes (Fig 1B) . 172

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