A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors

Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan

UBERON:0008952). The Benjamini-Hochberg FDR control algorithm was applied to adjust 557 the p values of the resulting eQTL associations to identify only significant (FDR < 0.05) lung-558 specific SNP-gene spatial relationships in the ACE locus. 559 560 S2 Figure. The eQTL data used in this study was obtained from lung samples taken from 561 middle-aged individuals. To assess the correlation of genetic variation with the changes in 562 gene expression, the GTEx project (https://gtexportal.org/home/) collected and analysed lung 563 samples from donors who were densely genotyped. The age-distribution graph illustrates that 564 approximately 70% of the lung samples that were obtained were from donors aged between 50 565 and 60. 566 567 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.042002 doi: bioRxiv preprint . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a