Selected article for: "binding protein and heme binding protein"
Author: Jacob E. Choby; Hanna B. Buechi; Allison J. Farrand; Eric P. Skaar; Matthew F. Barber
Title: Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus
  • Document date: 2018_6_7
    • ID: ieh5cvw1_19
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/339705 doi: bioRxiv preprint the virulence of S. aureus relative to another human skin commensal, S. epidermidis (42). As such, we 265 cannot definitively conclude that IsdB evolution has been driven by selection during invasive disease. It 266 is also likely that variation across IsdB of S. aureus, S. argenteus, and S. schweitzeri.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/339705 doi: bioRxiv preprint the virulence of S. aureus relative to another human skin commensal, S. epidermidis (42). As such, we 265 cannot definitively conclude that IsdB evolution has been driven by selection during invasive disease. It 266 is also likely that variation across IsdB of S. aureus, S. argenteus, and S. schweitzeri may be the results 267 of antigenic variation to evade the immune system. By focusing on the hemoglobin binding pocket of 268 IsdB, we have been able to pinpoint critical variation for hemoglobin specificity. Previous studies have illustrated how mutations in hemoglobin coding or regulatory regions can 280 have highly deleterious effects on heme binding, oxygen affinity, and protein stability (43, 44) . In addition 281

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