Selected article for: "heme binding and oxygen affinity"

Author: Jacob E. Choby; Hanna B. Buechi; Allison J. Farrand; Eric P. Skaar; Matthew F. Barber
Title: Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus
  • Document date: 2018_6_7
  • ID: ieh5cvw1_20
    Snippet: to aforementioned sickle-cell alleles, dozens of hemoglobin mutations in humans have been reported 282 that contribute to genetic disease, including anemia and thalassemia (45). Thus, despite identifying 283 particular sites that are highly divergent among primates, much of the globin gene content is constrained 284 due to purifying selection. In future work it would be useful to determine how variation among primate 285 globins impacts other end.....
    Document: to aforementioned sickle-cell alleles, dozens of hemoglobin mutations in humans have been reported 282 that contribute to genetic disease, including anemia and thalassemia (45). Thus, despite identifying 283 particular sites that are highly divergent among primates, much of the globin gene content is constrained 284 due to purifying selection. In future work it would be useful to determine how variation among primate 285 globins impacts other endogenous biochemical functions, such as heme binding and oxygen affinity. 286

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