Selected article for: "beta distribution and positive selection"
Author: Jacob E. Choby; Hanna B. Buechi; Allison J. Farrand; Eric P. Skaar; Matthew F. Barber
Title: Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus
  • Document date: 2018_6_7
    • ID: ieh5cvw1_43
    Snippet: Likelihood ratio tests (LRTs) were performed by comparing pairs of site-specific models (NS sites): M1 365 (neutral) with M2 (selection), M7 (neutral, beta distribution of dN/dS<1) with M8 (selection, beta 366 distribution, dN/dS>1 allowed). Additional tests which also account for synonymous rate variation and 367 recombination, including FUBAR, FEL, and MEME, were performed using the HyPhy software package 368 via the Datamonkey server (49, 50)......
    Document: Likelihood ratio tests (LRTs) were performed by comparing pairs of site-specific models (NS sites): M1 365 (neutral) with M2 (selection), M7 (neutral, beta distribution of dN/dS<1) with M8 (selection, beta 366 distribution, dN/dS>1 allowed). Additional tests which also account for synonymous rate variation and 367 recombination, including FUBAR, FEL, and MEME, were performed using the HyPhy software package 368 via the Datamonkey server (49, 50). Sites under positive selection were mapped onto three-dimensional 369 molecular structures using Chimera (51) (http://www.cgl.ucsf.edu/chimera/). 370

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