Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_8
Snippet: To date, 7 pathogenic HCoVs (Figure 2A and 2B) have been found [1, 27] : (i) 2019-nCoV, SARS-CoV, MERS-CoV, HCoV-OC43, and HCoV-HKU1 are b genera, and (ii) HCoV-NL63 and HCoV-229E are a genera. We performed the phylogenetic analyses using the whole genome sequence data from 15 HCoVs to inspect the evolutionary relationship of 2019-nCoV with other HCoVs. We found that the whole genomes of 2019-nCoV had ~99.99% nucleotide sequence identity across t.....
Document: To date, 7 pathogenic HCoVs (Figure 2A and 2B) have been found [1, 27] : (i) 2019-nCoV, SARS-CoV, MERS-CoV, HCoV-OC43, and HCoV-HKU1 are b genera, and (ii) HCoV-NL63 and HCoV-229E are a genera. We performed the phylogenetic analyses using the whole genome sequence data from 15 HCoVs to inspect the evolutionary relationship of 2019-nCoV with other HCoVs. We found that the whole genomes of 2019-nCoV had ~99.99% nucleotide sequence identity across three diagnosed patients (Supplementary Table S1 ). The 2019-nCoV shares the highest nucleotide sequence identity (79.7%) with SARS-CoV among the 6 other known pathogenic HCoVs, revealing conserved evolutionary relationship between 2019-nCoV and SARS-CoV (Figure 2A ).
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