Selected article for: "cell receptor and key protein"
Author: Du, Lanying; He, Yuxian; Zhou, Yusen; Liu, Shuwen; Zheng, Bo-Jian; Jiang, Shibo
Title: The spike protein of SARS-CoV — a target for vaccine and therapeutic development
  • Cord-id: 48ay8yl3
  • Document date: 2009_2_9
    • ID: 48ay8yl3
    Snippet: Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as we
    Document: Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.

    Search related documents:
    Co phrase search for related documents
    • acid protease and acute respiratory syndrome sars cov coronavirus: 1, 2, 3, 4, 5, 6, 7
    • acidic environment and acute respiratory syndrome sars cov coronavirus: 1, 2, 3, 4
    • acidic environment and liver lymph: 1, 2
    • acidic environment and liver lymph node: 1, 2
    • acute phase and liver damage: 1, 2, 3, 4, 5, 6
    • acute phase and long period: 1, 2, 3
    • acute respiratory syndrome sars cov coronavirus and adaptive evolution: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute respiratory syndrome sars cov coronavirus and liver damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome sars cov coronavirus and liver lymph: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute respiratory syndrome sars cov coronavirus and liver lymph node: 1, 2, 3
    • acute respiratory syndrome sars cov coronavirus and long period: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome sars cov coronavirus and low antiviral potency: 1, 2
    • liver damage and long period: 1, 2