Selected article for: "antiviral therapy and differential diagnosis"
Author: Guerini, Andrea Emanuele; Borghetti, Paolo; Filippi, Andrea Riccardo; Bonù, Marco Lorenzo; Tomasini, Davide; Greco, Diana; Imbrescia, Jessica; Volpi, Giulia; Triggiani, Luca; Borghesi, Andrea; Maroldi, Roberto; Pasinetti, Nadia; Buglione, Michela; Magrini, Stefano Maria
Title: Differential diagnosis and clinical management of a case of COVID-19 in a stage III lung cancer patient treated with radio-chemotherapy and durvalumab.
  • Cord-id: k9hut687
  • Document date: 2020_6_2
    • ID: k9hut687
    Snippet: BACKGROUND: pneumonitis is common in NSCLC and can be a consequence of the disease itself, super-infection, or side effects of the treatment. Recently Covid-19 added to the list of possible causes, emerging as a concrete threat for already frail patients. CASE REPORT: a 75-years-old stage-III NSCLC patient underwent radical radio-chemotherapy followed by consolidation durvalumab at our Institution. After four cycles, immunotherapy was suspended due to symptomatic pneumonitis responsive to oral s
    Document: BACKGROUND: pneumonitis is common in NSCLC and can be a consequence of the disease itself, super-infection, or side effects of the treatment. Recently Covid-19 added to the list of possible causes, emerging as a concrete threat for already frail patients. CASE REPORT: a 75-years-old stage-III NSCLC patient underwent radical radio-chemotherapy followed by consolidation durvalumab at our Institution. After four cycles, immunotherapy was suspended due to symptomatic pneumonitis responsive to oral steroids. Nevertheless, he suddenly developed fever and severe dyspnea. Chest radiography described diffuse alveolar and interstitial infiltrates and RT-PCR confirmed the diagnosis of Covid-19. His clinical conditions worsened despite antiviral therapy and supplemental oxygen and the patient died three days after admission. DISCUSSION: this paper highlights the remarkable clinical and radiological similarity of pneumonitis causated by Covid-19 and immunotherapy, hampering differential diagnosis and corroborating the hypothesis that inflammatory molecules, and possibly PD-L1, play a central role in Covid-19 pathogenesis.

    Search related documents:
    Co phrase search for related documents
    • abdominal computed tomography and admission day: 1
    • abdominal computed tomography and liver function: 1
    • abdominal computed tomography and lung involvement: 1
    • acute phase and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute phase and liver function: 1, 2, 3, 4, 5, 6, 7
    • acute phase and lopinavir ritonavir: 1, 2, 3, 4, 5
    • acute phase and lung dysfunction: 1, 2, 3, 4, 5, 6, 7
    • acute phase and lung involvement: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • admission day and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • admission day and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • admission day and low middle: 1, 2, 3
    • admission day and lung dysfunction: 1, 2
    • admission day and lung involvement: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • liver function and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • liver function and low middle: 1, 2, 3
    • liver function and lung involvement: 1, 2
    • liver function creatinine and low middle: 1
    • lopinavir ritonavir and low middle: 1, 2, 3
    • lopinavir ritonavir and lung dysfunction: 1