Author: Sarah Krieg; Fabian Pott; Laura Eckei; Maud Verheirstraeten; Mareike Bütepage; Barbara Lippok; Christine Goffinet; Bernhard Lüscher; Patricia Verheugd
Title: Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2 Document date: 2020_1_8
ID: 2vecg9op_19
Snippet: Mechanistically, our results provide evidence for inhibition of the nsP2 protease function, 325 which is essential for viral replication, by ARTD10-dependent MARylation. This results in a 326 defect in CHIKV polyprotein processing and consequently in reduced replication. This 327.....
Document: Mechanistically, our results provide evidence for inhibition of the nsP2 protease function, 325 which is essential for viral replication, by ARTD10-dependent MARylation. This results in a 326 defect in CHIKV polyprotein processing and consequently in reduced replication. This 327
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