Author: Kumavath, Ranjith; Barh, Debmalya; Andrade, Bruno Silva; Imchen, Madangchanok; Aburjaile, Flavia Figueira; Ch, Athira; Rodrigues, Diego Lucas Neres; Tiwari, Sandeep; Alzahrani, Khalid J.; Góes-Neto, Aristóteles; Weener, Marianna E.; Ghosh, Preetam; Azevedo, Vasco
Title: The Spike of SARS-CoV-2: Uniqueness and Applications Cord-id: 4n3bt06h Document date: 2021_7_8
ID: 4n3bt06h
Snippet: The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In this review, we have initially performed a meta-analysis of keywords associated with the S protein to frame the outline of important research findings and directions related to it. Based on this outline, we have reviewed the structure, uniqueness, and origin of the S protein of SARS-CoV-2. Furthermore, the interactions of the Spike protein w
Document: The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In this review, we have initially performed a meta-analysis of keywords associated with the S protein to frame the outline of important research findings and directions related to it. Based on this outline, we have reviewed the structure, uniqueness, and origin of the S protein of SARS-CoV-2. Furthermore, the interactions of the Spike protein with host and its implications in COVID-19 pathogenesis, as well as drug and vaccine development, are discussed. We have also summarized the recent advances in detection methods using S protein-based RT-PCR, ELISA, pointâ€ofâ€care lateral flow immunoassay, and graphene-based field-effect transistor (FET) biosensors. Finally, we have also discussed the emerging Spike mutants and the efficacy of the Spike-based vaccines against those strains. Overall, we have covered most of the recent advances on the SARS-CoV-2 Spike protein and its possible implications in countering this virus.
Search related documents:
Co phrase search for related documents- acute sars respiratory syndrome coronavirus and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute sars respiratory syndrome coronavirus and long term adaptive: 1
- acute sars respiratory syndrome coronavirus and low concentration: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42
- acute sars respiratory syndrome coronavirus and low identity: 1
- acute sars respiratory syndrome coronavirus and low sensitivity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56
- acute sars respiratory syndrome coronavirus and low similarity: 1, 2
- acute sars respiratory syndrome coronavirus and lung compare: 1, 2, 3
- acute sars respiratory syndrome coronavirus and lung express: 1, 2, 3
- acute sars respiratory syndrome coronavirus and lysosomal cathepsin: 1, 2, 3
- adaptive mutation and long term adaptive: 1
- liver injury and low concentration: 1
- liver injury and low sensitivity: 1, 2
Co phrase search for related documents, hyperlinks ordered by date